2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel

Calcium Channel

Ca2+ channels; Ca channels

Calcium Channel

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Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Calcium Channel Isoform Specific Products:

Calcium Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-162374
    ANO61
    		Inhibitor
    ANO61 is a dibenzyl formamide derivative, which exhibits an antiplatelet efficacy through modulation of thrombin-induced Ca2+ response with an IC50 of 47.7 μM.
    ANO61
  • HY-A0057AS2
    Gabapentin-d4 hydrochloride
    		Inhibitor
    Gabapentin-d4 hydrochloride is the deuterium labeled Gabapentin hydrochloride (HY-A0057A). Gabapentin hydrochloride is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin hydrochloride inhibits neuronal Ca2+ influx and reduction of neurotransmitter release. Gabapentin hydrochloride is a GABA analog that can be used to relieve neuropathic pain.
    Gabapentin-d<sub>4</sub> hydrochloride
  • HY-B0612ES
    (S)-Lercanidipine-d3 hydrochloride
    (S)-Lercanidipine-d3 (hydrochloride) is a deuterium labeled Lercanidipine D3 hydrochloride. (S)-Lercanidipine hydrochloride is an antihypertensive agent[1].
    (S)-Lercanidipine-d<sub>3</sub> hydrochloride
  • HY-B0317BR
    Amlodipine besylate (Standard)
    		Antagonist
    Amlodipine (besylate) (Standard) is the analytical standard of Amlodipine (besylate). This product is intended for research and analytical applications. Amlodipine besylate (Amlodipine benzenesulfonate), an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine besylate can be used for the research of high blood pressure and cancer.
    Amlodipine besylate (Standard)
  • HY-117099
    TMB-8
    		Antagonist
    TMB-8 is a novel Ca 2+ antagonist. TMB-8 may exert inhibitory effects in smooth muscle by blocking Ca 2+ release from intracellular bound stores.
    TMB-8
  • HY-148863
    Cavα2δ1&NET-IN-2
    		Inhibitor
    Cavα2δ1&NET-IN-2 (Compound 45CS) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-2 inhibits Cavα2δ-1 with a Ki of 454 nM. Cavα2δ1&NET-IN-2 inhibits NET with a Ki of 59 nM and IC50 of 7 nM. Cavα2δ1&NET-IN-2 can be used for research of pain.
    Cavα2δ1&NET-IN-2
  • HY-N0215S2
    L-Phenylalanine-13C
    		Antagonist
    L-Phenylalanine-13C is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
    L-Phenylalanine-<sup>13</sup>C
  • HY-116746
    Clopimozide
    		Antagonist
    Clopimozide is an orally active antischizophrenic agent that inhibits [3H]nitrendipine binding with IC50 value of 17 nM. Clopimozide is a calcium channel antagonist. Clopimozide can be used for the research of negative and positive schizophrenic symptoms.
    Clopimozide
  • HY-101607
    KT-362
    		Antagonist
    KT-362 is an intracellular calcium antagonist. KT-362 can inhibit NE-induced contractions and IP accumulation in vivo experiments.
    KT-362
  • HY-112348
    HA-1004 hydrochloride
    		Inhibitor
    HA-1004 hydrochloride is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 hydrochloride is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein (Cyclic GMP-AMP Synthase), and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 hydrochloride an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models.
    HA-1004 hydrochloride
  • HY-B0282AS2
    Acetylcholine-d13 bromide
    		98.55%
    Acetylcholine-d13 (bromide) is the deuterium labeled Acetylcholine bromide[1].
    Acetylcholine-d<sub>13</sub> bromide
  • HY-111613S
    Pinaverium bromide-d4
    		Inhibitor
    Pinaverium bromide-d4 is deuterium labeled Pinaverium bromide. Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract, effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients[1].
    Pinaverium bromide-d<sub>4</sub>
  • HY-B0166S5
    L-Ascorbic acid-13C-4
    L-Ascorbic acid-13C-4 is the 13C labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collag
    L-Ascorbic acid-<sup>13</sup>C-4
  • HY-111245
    AZD-1305
    		Inhibitor
    AZD-1305 is an antiarrhythmic agent and atrial selective sodium channel/potassium channel blocker, which can significantly prolongs action potential duration and reduces excitability, cause atrial selective ERP prolongation and acute termination of atrial fibrillation. AZD1305 can be used for atrial fibrillation research.
    AZD-1305
  • HY-B1640S
    Ethacrynic acid-13C2,d5
    Ethacrynic acid-13C2,d5 is the deuterium and 13C labeled Ethacrynic acid.
    Ethacrynic acid-<sup>13</sup>C<sub>2</sub>,d<sub>5</sub>
  • HY-B0265S
    Nimodipine-d7
    		Inhibitor 99.35%
    Nimodipine-d7 is the deuterium labeled Nimodipine. Nimodipine (BAY-e 9736) is an orally active, well-tolerated and light-sensitive dihydropyridine calcium antagonist. Nimodipine can be used for the research of cerebrovascular disorders[1].
    Nimodipine-d<sub>7</sub>
  • HY-N0252R
    Catharanthine (Standard)
    		Inhibitor
    Catharanthine (Standard) is the analytical standard of Catharanthine. This product is intended for research and analytical applications. Catharanthine ((+)-3,4-Didehydrocoronaridine), a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC). Catharanthine has IC50s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine lowers blood pressure (BP), heart rate (HR). Catharanthine has anti-cancer activity.
    Catharanthine (Standard)
  • HY-P5804
    ω-Conotoxin CVIF
    		Inhibitor
    ω-Conotoxin CVIF is a selective Cav2.2 channel inhibitor with an IC50 of 34.3 nM in rat isolated DRG neurons. ω-Conotoxin CVIF block of Cav2.2 channels is weakly reversible.
    ω-Conotoxin CVIF
  • HY-135110
    Rp-8-Br-cGMPS sodium
    		Activator
    Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca2+-ATPase activator. Rp-8-Br-cGMPS is also an agonist of the rod CNG channel and an inhibitor of PKG. Rp-8-Br-cGMPS sodium salt mediates cytosolic Ca2+ reduction by activating Ca2+-ATPase and subsequently removing Ca2+ from the cell.
    Rp-8-Br-cGMPS sodium
  • HY-N0601R
    Ginsenoside Rf (Standard)
    		Inhibitor
    Ginsenoside Rf (Standard) is the analytical standard of Ginsenoside Rf. This product is intended for research and analytical applications. Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.
    Ginsenoside Rf (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
Calcium Channel Isoform Comparison

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